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Cambridge Life Sciences - Immunology - Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) and Crohn's Disease (CD)

Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

Inflammatory Bowel Disease (IBD) are characterised by chronic inflammation and ulceration of the intestine. Atypical pANCA have been reported to occur in patients with IBD and primary sclerosing cholangitis (PSC). Studies have shown that ~80% of patients with NC and PSC and ~25% of patients with Crohn's disease have pANCA. Atypical pANCA occur in patients with UC. Bacterial permealising increasing factor (BPI) is one of the antigens associated with a pANCA reaction in patients with UC.

Immunofluorescence Assays

Code	Name	Description	Determinations
1116	ImmuGlo ANCA IFA Kit	4 x 6 well hPMN ethanol fixed	24
1140	ImmuGlo ANCA IFA Kit	8 x 6 well hPMN ethanol fixed	48
1141	ImmuGlo pANCA IFA Kit	8 x 6 well hPMN formalin fixed	48
1142	ImmuGlo COMVI ANCA IFA Kit	8 x 6 + 6 well hPMN ethanol and formalin fixed	48
2189	ImmuGlo ANCA COMVI Slide	ethanol and formalin fixed hPMN cells	6+6 well
2162	ImmuGlo ANCA Slide	6 well ethanol fixed hPMN cells	6 well
2186	ImmuGlo pANCA Slide	6 well formalin fixed hPMN cells	6 well
2252	ImmuGlo ANCA positive control		0.5mL
2240	ImmuGlo pANCA positive control		0.5mL
2220	ImmuGlo negative control		0.5mL
2100	ImmuGlo IgG FITC Conjugate	anti-human IgG for Indirect IF	5.0mL
For technical information on Immco products please click here or contact us.

Anti-Saccharomyces Cerevisiae Antibodies (ASCA)

Differentation of Crohn's Disease (CD) and Ulcerative Colitis (UC) can be problematic clinically. ASCA and ANCA studies are useful in screening tests for IBD in differentiating UC from CD and in proper identification of patients with indeterminate colitis.

The staining pattern of ANCA in IBD is atypical pANCA. The prevalence of pANCA in UC is 50-80% while in CD the prevalence is 10-20%. In contrast, ASCA occur primarily in CD (50-60%) and rarely in UC.

D-tek BlueWell Elisa

Code	Name	Description	Determinations
ASCA02-96	ASCA IgA Elisa	Anti Saccharomyces Cerevisiae IgA antibody Elisa	96
ASCG02-96	ASCA IgG Elisa	Anti Saccharomyces Cerevisiae IgG antibody Elisa	96
ASCS02-96	ASCA IgA/IgG Screen Elisa	Anti Saccharomyces Cerevisiae IgA/IgG antibody Elisa	96
For technical information on D-tek products please click here or contact us.

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